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Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS) Naoki Atsuta 1 , Ryoichi Nakamura 1 , Hazuki Watanabe 1 , Gen Sobue 1 1Department of Neurology, Nagoya University Hospital and Nagoya University Graduate School of Medicine Keyword: amyotrophic lateral sclerosis (ALS) , disease cohort , genome DNA , prognostic factor pp.1090-1096
Published Date 2014/9/1
DOI https://doi.org/10.11477/mf.1416101890
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Abstract

To investigate the longitudinal course of Japanese patients with amyotrophic lateral sclerosis (ALS), we have designed a multicenter registration and follow-up system called Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS). Genomic DNA samples and B-cell lines from patients with ALS were stored and linked to their clinical information. We designed a telephone survey system involving clinical research coordinators to check the patients' scores on the ALS Functional Rating Scale-revised and their prognoses every 3 months. In February 2006, we began registering patients with ALS. Currently, 30 neurology institutions are participating in the JaCALS, and 905 patients with ALS are registered. The JaCALS has established an efficient registration and follow-up system linking genomic information from patients with ALS. We believe this consortium will contribute to clinical research in ALS.


Copyright © 2014, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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