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症例は初診時76歳の男性。排尿困難を主訴に受診。中分化型腺癌stage Cと診断。酢酸クロルマジノン(CMA)100mg/日による治療開始2年7か月後に仮性再燃。ホスフェストロール300mg/日投与にて2か月で軽快し,再びCMA lOO mg/日投与を続けた。さらにその1年後より再燃し,フルタミド375mg/日を開始した。3か月でPSAは正常化した。その後1年5か月は,LH-RHアナログとの併用にて経過は良好である。確定診断,治療開始後5年8か月の現在,81歳にて外来通院中である。
The patient was 76 years old and diagnosed stage C moderately differentiated adenocarcinoma. Initially, chlormadinone acetate (100 mg/day) was effective and PSA level was completely suppressed. After 2 years, the patient discontinued medication for about 6 months and diethylstilbestrol was given for short period to control the progression of tumor. After 3 years and 9 months, his prostate cancer relapsed and flutamide (375 mg/day) was administered. A complete response of PSA within 3 months was demonstrated and thereafter his prostate was well controlled for 17 months with LH-RH analogue and flutamide.
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