慢性透析における1-αVitamin D3の効果について

STUDY ON EFFECTS OF 1-α HYDROXYCHOLECALCIFEROL ON CHRONIC HEMODYALYSIS

緒言

　血液透析の一般化に伴い，慢性腎不全症例のCa代謝異常が大きく注目を集めるようになつた。そしてこれと共にイオン化Ca（以下Ca^＋＋と略）や，副甲状腺ホルモン（以下PTHと略）の臨床レベルでの測定も可能となり，後者ではN末端，C末端の分離測定も行なわれるようになつた。またVitamin D₃（以下D₃と略）の各種誘導体も測定し得るに及び，この面の知識も急速に豊富になつて来た。その上，治療的にもD₃の誘導体の投与が可能となつた。今回われわれもD₃誘導体の一つである1-α　Hydroxycholecalciferol（以下1-_αD₃と略）の投与を行ない，二，三の知見を得たのでその結果を報告する。

During the period covering December 1978 through August 1979, six male adults with chronic renal failure were orally given 1-α hydroxycholecalciferol. In the first 3 months period, 5 cases under dialysis for 6 months to 5 years, received 0.5μg/day. In the 2 nd period which was from May to August, 2 cases out of the above 5 cases who did not show any effect and one new case were started with 0.75 μg/day. In 2 cases who had not shown any effect after the first period, dosis was changed to 1μg/day in the course of the therapy while the new case began to show hypercalcemia, in which dosis was reduced to 0.25μg/day.