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A CASE OF SYSTEMIC MASTOCYTOSIS Nobuya SAITO 1 1Department of Dermatology, Tohoku University School of Medicine pp.347-352
Published Date 1968/4/1
DOI https://doi.org/10.11477/mf.1412200314
  • Abstract
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A case of systemic mastocytosis in a 17-year-old girl was reported. Nothing contributive was found in her past and family history.

History of present illness : Small reddish papules appeared on the abdomen about the age of three, which covered the entire body surface within half a year. No bulla formation was noted and there were no subjective sensations such as itching.

Present status : On hospitalization, many reddish-brown, soft, slightly elevated, small papules covered the entire body surface, except for the scalp, palms and soles, closely and in retiform arrangement. Urtication by stroking was markedly positive on the papules. No swelling of the lymph nodes, liver, and spleen could be proved.

Laboratory findings : Hematologic studies on the peripheral blood showed normal results, except for slightly increased mast cells. The results of chemical studies on the blood scrum were within normal limits. No pathologic findings were found in roentgenograms of the bones. A marked increase (15.6%) of mast cells was revealed in the bone marrow.

Considerable increases in free histamine in the urine (447.2 μg/day) and in the skin lesions (484.2 μg/day) were proved, but there were no symptoms and signs due to the excessive histamine release.

Histopathologic specimen of the lesion showed a dense mast cell infiltrate in the upper and mid dermis.

This is the reported fourth case in Japan.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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