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Japanese

TOXIC EPIDERMAL NECROLYSIS (LYELL): AN AUTOPSIED CASE Tatsuro MASUMIZU 1 , Kyoko HIRANO 1 , Kinya KONO 2 1Department of Dermatology, Nippon University School of Medicine 2Department of Clinical Pathology, Nippon University School of Medicine pp.337-345
Published Date 1968/4/1
DOI https://doi.org/10.11477/mf.1412200313
  • Abstract
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 A 50-year-old man was hospitalized with diffuse erythema and erosion over the entire body surface and serious general conditions. Three days after admission he died, and autopsy was performed.

 Three cases of autopsy in Japan and eleven from abroad have been reported. Many of them showed decreased lipid or necrosis of the adrenal cortex, and necrosis of the epidermis. Its on-set is quite abrupt.

 The pathomechanism of this disease might be autoimmunity to the epidermis or anaphylaxis on the epidermis as a shock organ. Dysproteinemia, beneficial effect of steroid hormone, LE phenomenon-like reaction, and findings suggesting allergic reaction might support this view.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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