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CLINICO-PATHOLOGICAL STUDIES ON DRUG ERUPTION Hikotaro YOSHIDA 1 , Kimiyoshi ONO 1 1Department of Dermatology, Okayama University School of Medicine pp.979-991
Published Date 1967/9/1
DOI https://doi.org/10.11477/mf.1412200213
  • Abstract
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Although it has been well known fact that penipheral blood picture and liver function tests give the specific changes in systemic drug allergy, those changes in severe aller-gic eruption of drug are not known.

This study of 9 cases of drug eruption was performed to know how these specific patterns of laboratory results of systemic drug allergy could be modified by the severe and widesp-read skin manifestations.

1) The main change of peripheral blood picture was the nonspecific inflammatory reaction, where the specific findings for systemic drug allergy such as granulocytopenia, anemia and thrombocytopenia were masked by the drug eruption. However some cases showed the nonspecific blood picture in the early stage and the specific findings in the late stage.

2) Few cases showed the specific test pattern of altered liver function for drug allergy such as hepatitis-type or intrahepatic gall retention-type. The cases which showed definite changes of liver function tests due to the damaged skin by drug allergy could not be proved.


Copyright © 1967, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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