味覚異常を主訴とし亜鉛投与で改善を認めたCronkhite-Canada症候群の1症例

Improvement of Cronkhite-Canada Syndrome with Taste Disorder treated with Zinc Sulfate

　はじめに

　Crokhite-Canada症候群^1）は非遺伝性で多くは中年以後に発症し，消化管ポリポージス，皮膚の色素沈着，脱毛，爪甲の萎縮・脱落を四主徴とする稀な疾患であり，原因はなお不明である。しかし過去の報告を検討すると味覚障害を初発症状として発症している報告も多く^2），本症候群と味覚障害とは何らかの関係があると推定される。今回味覚障害を主訴としてCronkhite-Canada症候群と診断し得た症例に対して，亜鉛内服療法を行ったところ，諸症状の改善を認めたので，若干の考察を加えて報告する。

A 65-year-old man with Cronkhite-Canada syn-drome complained of taste disorder. This patient was attacked with diarrhea and general malaise and visited our hospital with a major complaint of gustatory dullness. Polyposis in the stomach and the duodenum accompanied by pigmentation in the hands and feet, nail atrophy, and easy fatigability was detected. Increased threshold ofthe chorda tympani was found on gustometry, but it was improved by administration of zinc sulfate, and the above-mentioned symptoms were also improved. From these findings, it was thought that this syndrome should be considered as a zinc deficiency syndrome caused by gastrointestinal polyposis.