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Japanese

Clinical analysis of advanced melanoma treated with anti-PD-1 antibody(nivolumab) Masahito Minagi 1 , Ikuo Inokuchi 1 , Nobuaki Ayada 1 , Kentaro Egusa 1 , Ichiro Fukumasu 1 , Shinya Morita 2 , Shin Kariya 2 1Department of Otolaryngology-Head and Neck Surgery, Hiroshima City Hiroshima Citizens Hospital pp.379-386
Published Date 2020/4/20
DOI https://doi.org/10.11477/mf.1411202346
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 Malignant melanoma is a highly aggressive cancer, and it is difficult to manage. Nivolumab, a fully human monoclonal antibody against programmed death receptor-1, was approved for the treatment of unresectable malignant melanoma in 2014 in Japan. In this study, we showed the effect as well as the adverse reactions of nivolumab in melanoma. Four patients with melanoma arising in the head and neck received nivolumab, and one patient showed a complete response. Three adverse events were observed in patients with head and neck melanoma:uveitis, arthritis, and vitiligo.


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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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