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Consciousness disturbance caused by voriconazole in a patient with invasive fungal sinusitis Hidetoshi Matsui 1 1Department of Otolaryngology,Kobe medical center pp.865-869
Published Date 2011/10/20
DOI https://doi.org/10.11477/mf.1411101982
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 A case of consciousness disturbance due to voriconazole(VRCZ)for invasive sphenoidal aspergillosis was reported. A 61-year-old woman presented with a complaint of headache,diplopia,right-sided blepharoptosis and exophthalmos. Clinical findings and imaging studies showed that she had invasive sphenoidal fungal sinusitis. Immediately she was treated with 400 mg/day of VRCZ and underwent endoscopic sphenoidotomy. On the postoperative day(POD)2,her symptoms significantly improved. However,on POD 3,she suffered from visual and auditory hallucination. Afterwards,her consciousness deteriorated into Japan Coma Scale 200. On POD 9,administration of VRCZ was discontinued. Subsequently,her symptoms were resolved.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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