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I.はじめに
分化型甲状腺癌は一般に発育が緩徐であり,比較的予後良好とされている。治療法は,化学療法や外照射による放射線治療は効果が期待できず外科的摘出が主体となる。遠隔転移をきたした症例に対しては131Iによるアイソトープ治療が施行されることが一般的であり,その有用性については既に多くの報告がある。
今回われわれは,過去 7年間に131Iによるアイソトープ治療を施行した分化型甲状腺癌遠隔転移例20例について,安全性,治療効果などについて検討し,その適応について再考した。
Between 1994~2000,20 patients with distant metastasis of differentiated thyroid carcinoma (19 papillary carcinoma and 1 follicular carcinoma) have been treated with 131I following total thyroidectomy.
The age at therapy ranged from 18~76 years. Of the 20 patients,17 patients had lung metastasis,4 bone metastasis and 3 lymph node metastasis. A therapeutic dose of 131I was 100mCi.
The rate of response to therapy was 35% (7/20). There was no significant relationship between age and the rate of response to the therapy. The rate of response to the therapy to lung metastasis was 24% (4/17),to bone metastasis was 75% (3/4). Side effects were hardly shown. From these results,it may be concluded that 131I therapy is safe and suitable therapy to differentiated thyroid cancer with distant metastasis.
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