糖尿病網膜症と血清ヘモグロビン濃度の関係

Diabetic retinopathy and serum hemoglobin levels

　糖尿病網膜症の程度と末梢血ヘモグロビン濃度の関係を306人について検索した。網膜症の程度を3群に分けた。網膜症なし（Ⅰ群），光凝固の既往のない単純網膜症（Ⅱ群），重度網膜症（Ⅲ群）であり，Ⅲ群には光凝固の既往のある単純網膜症，前増殖網膜症，増殖網膜症を含むものとした。ヘモグロビン濃度の平均値を，男女別と，年代層別（50歳未満，50,60,70歳台，80歳以上）に設定した。低ヘモグロビンの頻度は，Ⅰ群44.1％，Ⅱ群27.9％，Ⅲ群27.9％あり，高ヘモグロビンの頻度は，Ⅰ群57.7％，Ⅱ群23.5％，Ⅲ群18.8％であり，ヘモグロビン低値者と高値者間に有意差があった（p＜0.05,X²検定）。この結果は，糖尿病網膜症の程度とヘモグロビン濃度との間に正の相関があることを示している。

We evaluated 306 patients of diabetic retinopathy regarding peripheral blood hemoglobin levels. The cases were divided into 3 groups : no retinopathy (groupⅠ) , simple retinopathy without photocoagulation (group Ⅱ) , and preproliferative or proliferative retinopathy including simple retinopathy after photocoagulation (group Ⅲ) . Normal values for hemoglobin levels were set for either sex and different age groups: below 50 years, 6th, 7th, 8th decade and over. The incidence of low hemoglobin was 44.1% in group Ⅰ , 27.9% in group Ⅱ and 27.9% in group Ⅲ. That of high hemoglobin was 57.7% in group Ⅰ , 23.5% in group Ⅱ and 18.8% in group Ⅲ. The incidence of advanced retinopathy was thus significantly higher in low hemoglobin group than in high hemoglobin group (p＜0.05). Neither sex nor age was a significant factor. The findings show that low hemoglobin level is a risk factor for progression of diabetic retinopathy.