The effect of botulinum toxin type A on blepharospasm Kazuaki Mishima 1 , Yasuo Tsuda 1 , Yuko Deguchi 1 , Asuka Ogawa 1 , Hirohiko Hayashida 1 , Takashi Kitaoka 1 , Tsugio Amemiya 1 1Dept of Ophthalmol and Visual Sciences, Nagasaki Univ Sch of Med pp.249-252
Published Date 2002/3/15
DOI https://doi.org/10.11477/mf.1410907623
  • Abstract
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We treated 43 patients of blepharospasm using botulinum toxin type A. The series comprised 33 cases of essential blepharospasm and 10 cases of Meige syndrome. There were 11 males and 32 females. Their ages averaged 65.5±10.6 years. Botulinum toxin was injected into 5 sites of orbicularis oculi in the eyelid and 1 site of its infraorbital portion. Remarkable improvement resulted in 36 cases (84%). Additional treatment became necessary after an ave-rage of 6.8±3.3 months. There was no complication throughout. The duration of improvement was longer that previ-ously reported, probably due to social and geographical peculiarities in the present series. These findings show that treatment of blepharospasm by botulinum toxin is safe and effective and that this therapeutic modality is to be pre-ferred to surgery particularly in senile patients.

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