Infiltrative optic neuropathy in a case of acute promyelocytic leukemia during remission induction therapy Akihiko Murata 1 , Kazuhiro Tokuda 1 , Naoki Kumagai 1 , Teruo Nishida 1 , Takatoshi Anno 2 , Yutaka Sato 2 , Yoshitomo Oka 2 1Dept of Ophthalmol, Yamaguchi Univ Sch of Med 2Dept of 3rd Internal Med, Yamaguchi Univ Sch of Med pp.1653-1658
Published Date 1999/9/15
DOI https://doi.org/10.11477/mf.1410906509
  • Abstract
  • Look Inside

A 14-year-old girl had been diagnosed as acute promyelocytic leukemia followed by remission induction chemotherapy resulting in hematological improvement. She noted visual failure in her left eye 17 days after initiation of therapy. Both eyes showed leukemic retinopathy. She later manifested bilateral swelling of optic nerve head and retinal detachment in the left eye. Magnetic resonance imaging showed swelling of the optic nerve and high-intensity signal around the optic disc. Critical flicker fusion was reduced. These findings led the diagnosis of infiltrative optic neuropathy. No leukemic cells were detected in the cerebrospinal fluid. Her eye findings improved after intravenous and intrachecal chemotherapy followed by radiation to the posterior eye segment. This case illustrates that severe optic neuropathy may manifest in leukemia with apparently improved hematological findings.

Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院