正常眼圧緑内障におけるニルバジピンの視野障害進行に対する効果

Effect of systemic nilvadipine on preventing progression of visual field defect in normal-tension glaucoma

（P4-3-17）　正常眼圧緑内障（NTG）10例10眼にCa2＋拮抗薬であるニルバジピン4mg／日を2年間内服投与し，同程度の年齢，屈折，視野障害を持つ非投与NTG症例10例10眼を対照として，視野障害進行を比較した。視野障害進行の評価は，Humphrey Field Analyzerのcentral 30-2 programを用い，網膜感度変化量を比較した。投与群は非投与群と比較し，投与2年後に平均網膜感度は有意に改善した（p＝0.005）。眼圧，平均血圧，脈拍，眼灌流圧に両群間に有意差はなかった。Ca2＋拮抗薬の1つであるニルバジピン長期内服は，NTGの視機能維持に対し有効であることが示唆された。

We performed a prospective study on the effect of nilvadipine, a calcium antagonist, on the visual field in 10 eyes of 10 patients with normal-tension glaucoma (NTG) . Another series of 10 eyes of 10 patients with NTG served as control. Both group showed similar features regarding age, refraction, visual field defect and topical antiglaucoma medica-tions. The visual field was assessed using the mean retinal sensitivity by Program 30-2 of Humphrey Field Analyzer. After 2 years of nilvadipine at the daily dose of 4 mg, the treated group showed improved mean retinal sensitivity as compard with the control group. The difference was significant (p=0.005). No significant difference was present between the two groups regarding intraocular pressure, mean blood pressure, heart rate, and intraocular perfusion pressure. These findings show the efficacy of oral nilvapidine on the visual function in NTG eyes.