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Effect of donepezil hydrochloride on normal-tension glaucoma Yukiko Yoshida 1 , Tetsuya Sugiyama 2 , Tsunehiko Ikeda 2 , Keita Utsunomiya 3 , Yasuharu Ogura 3 , Isamu Narabayashi 3 1Dept of Ophthalmol, Ujigawa Hosp 2Dept of Ophthalmol, Osaka Med Coll 3Dept of Radiol, Osaka Med Coll pp.1437-1441
Published Date 2007/8/15
DOI https://doi.org/10.11477/mf.1410101881
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Abstract. Background:Peroral donepezil hydrochloride is claimed to be effective for Alzheimer disease, by elevating concentration of acetylcholine in the brain resulting in improved recognition and intracerebral circulation. It has been reported that some cases of normal-tension glaucoma(NTG)show cerebral circulation similar to patients of Alzheimer disease. Purpose:To evaluate the effect of donepezil hydrochloride on NTG. Cases and Method:This study was made on 10 eyes of 5 NTG patients who showed cerebral circulation similar to Alzheimer disease by 123I-IMP SPECT. The series comprised 3 males and 2 females. Their age ranged from 64 to 79 years, average 69 years. They were given donepezil hydrochloride at the daily dosis of 5mg for 6 months. Circulation in the optic nervehead was measured by laser speckle flowmetry. Results:Circulation in the brain and optic nervehead significantly increased after 6 months of treatment. MD value by Humphrey tonometer improved in 5 eyes(50%). There was no change in intraocular pressure. Conclusion:Peroral donepezil hydrochloride may improve optic neuropathy in NTG through its neuroprotective action.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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