乳頭周囲網脈絡膜萎縮と緑内障との関連（第1報）人間ドック受診者についての検討

Association of parapapillary chorioretinal atrophy with glaucoma. Report 1, Findings in examinees of health check-up

　人間ドック受診者1,028人を対象に，乳頭周囲網脈絡膜萎縮であるZoneα（不規則な色素沈着の異常），Zoneβ（ブルッフ膜途絶による強膜露出部）の頻度と全身的因子，局所的因子との関連についてロジスティック回帰分析を用いて検討を行った。Zoneαは全体の67.0％，Zoneβは12.3％に認められ，Jonasらの報告とほぼ一致した結果となった。Zoneαと各因子との間には関連は認められなかった。Zoneβと中性脂肪HDLコレステロール，HbA_1c，β—リポ蛋白，収縮期血圧などの動脈硬化促進因子との関連が示唆された。

We evaluated 1,028 examinees of health check-up program regarding the incidence of parapapil-lary chorioretinal atrophy (PPA) and its associa-tion with local and systemic factors. PPA was classified into 2 categories, Zone α and Zone ,β according to Jonas. Zone a was defined as struc-tural and pigmentary irregularities and zone β as complete loss of retinal pigment epithelial cells. The incidence of zone α was 67.0% and that of zone β was 12.3%. When processed by multivariate analysis with logistic model, there was a tendency for zoneβ to be associated with serum triglyceride, HDL cholesterol and HbA_lc. It appeared that zone β may be associated with arteriosclerosis promot-ing factors.