妊娠中に発症した原田病の2症例

Vogt-Koyanagi-Harada disease in two pregnant females

　両眼の視力低下を主訴に初診し，典型的な原田病の臨床像を呈し，髄液検査で細胞増多がみられた妊娠5か月の26歳女性と，同様に両眼の視力低下で発症し，眼底所見，螢光眼底造影検査，髄液検査，免疫学的検査で原田病と診断した妊娠8か月の33歳女性に対し，プレドニゾロン200mgを初期量とする大量療法を行い，妊娠，出産経過，および出生児にも異常がなく治癒した2症例について報告した。

Two females, aged 26 and 33 years, developed Vogt-Koyanagi-Harada disease. Both were pregnant at 5 and 8 months respectively. Both showed bilateral serous retinal detachment, optic disc edema and pleocytosis in the cerebrospinal fluid. Fluorescein angiography in the second case showed leakage and pooling of dye in the posterior fundus in both eyes. Both cases were treated by systemic prednisolone with the initial dosis of 200 mg per day which was tapered off gradually. The ocular inflammation subsided with full recovery of visual acuity. Both gave birth to normal babies with no complications.