通年性アレルギー性結膜炎に対する抗アレルギー点眼液の眼誘発反応抑制効果

Inhibition of ocular provocation by antiallergic eyedrops in perennial allergic conjunctivitis

　ダニを発症抗原とする通年性アレルギー性結膜炎患者27例に，抗原による眼誘発試験を行い，2％disodium cromoglycate （DSCG），0.25％amlexanoxおよび0.05％ketotifen点眼液の涙液中ヒスタミン遊離抑制効果を検討した。右眼に抗アレルギー点眼液，左眼にplacebo点眼液を点眼し，10分後に，ダニ抗原液を点眼して，アレルギー反応を誘発した。抗アレルギー点眼液投与眼の誘発5分および10分後の涙液中ヒスタミン量は，対照眼に比べ有意なヒスタミン遊離抑制効果がみられた。DSCG, amlexanoxおよびketotifen点眼液はいずれも通年性アレルギー性結膜炎に対する有効な薬剤であると考えられた。

We evaluated the inhibitory effect of three antial-lergic eyedrops preparations on ocular provocation in 27 patients with perennial allergic conjunctivitis. Ocular provocation was induced by instillation of mite antigen (Dermatophagoides farinae) diluted 400 fold. As antiallergic eyedrops, we used 2 % disodium cromoglycate (DSCG), 0.25 % amlexanoxand 0.05 % ketotifen.

Each test subject received one of the antiallergic eyedrops in the right eye and placebo eyedrops in the left. Ten minutes later, mite antigen was in-stilled in both eyes. Histamine levels in the lacrimal fluid 5 and 10 minutes after provocation were sig. nificantly less in the right eye than in the control left eye. Topical DSCG, amlexanox and ketotifen were thus considered to be effective for perennial allergic conjunctivitis.