スギ花粉症に対するフルオロメトロン点眼液の眼誘発反応抑制効果

Inhibitory effect of 0.1% fluorometholone eye drops on induced ocular reactions in Japanese cedar pollinosis

　スギ花粉症患者11例に，季節外に，抗原による眼誘発試験を行い，0.1％フルオロメトロン（FML）点眼液の涙液中ヒスタミン遊離抑制効果を検討した。右眼にFML点眼液，左眼にplacebo点眼液を点眼し，10分後に，20倍希釈のスギ抗原液を点眼して、アレルギー反応を誘発した。FML投与眼の誘発5分および10分後の涙液中ヒスタミン量は，対照眼に比べ有意なヒスタミン遊離抑制効果がみられた（5分後：p＜0.01,10分後P＜0.02）。FML点眼液のヒスタミン遊離抑制率は，誘発5分後で69.7％，誘発10分後で67.9％であった。0.1％FML点眼液の抗アレルギー作用に，ヒスタミン遊離抑制効果が関与していると考えられた。

To evaluate the inhibitory effect of 0.1% fluor-ometholone (FML) eye drops on histamine release into lacrimal fluid, ocular provocation tests with antigen were performed in 11 patients with Japanese cedar pollinosis during the off-season. The patients received FML eye drops by topical application in their right eyes and placebo eye drops in their left eyes. Ten minutes later, cedar antigen solution at 1: 20 w/v was applied to theireyes to induce an allergic reaction. The amount of histamine in their lacrimal fluid 5 and 10 minutes after provocation indicated significantly greater inhibition of histamine release in the FML-treated eyes than in the control eyes (p＜0.01 after 5 minutes: p＜0.02 after 10 minutes). The rate of histamine release inhibition by FML eyes drops was 69.7% 5 minutes and 67.9% 10 minutes after provo-cation. These results suggest that the anti-allergic action of 0.1% FML eye drops may involve the effect of inhibiting histamine release.