スギ花粉症に対するketotifen点眼液の眼誘発反応抑制効果

Topical ketotifen suppressed ocular provocation for Japanese cedar pollinosis

　スギ花粉症患者11例に，季節外に，抗原による眼誘発試験を行い，0.05％ketotifen （HC）点眼液の涙液中ヒスタミン遊離抑制効果を検討した。右眼にHC点眼液，左眼にplacebo点眼液を点眼し，5分後に，20倍希釈のスギ抗原液を点眼して，アレルギー反応を誘発した。HC投与眼の誘発5分および10分後の涙液中ヒスタミン量は，対照眼に比べ有意なヒスタミン遊離抑制効果がみられた（P＜0.01）。HC点眼液のヒスタミン遊離抑制率は，誘発5分後で67.5％，誘発10分後で67.2％であった。0.05％HC点眼液はスギ花粉症に対する有効な薬剤であると考えられる。

We evaluated the value of 0.05% ketotifen (HC) ophthalmic solution in the inhibition of release of histamine in the tear fluid after eye provocation with antigen for Japanese cedar pollinosis. A series of 11 patients were tested during the off-season. HC was instilled in the right eye, while the left eye was given placebo eyedrops. Five minutes later, both eyes were instilled with cedar antigen solution at1:20 w/v. Levels of histamine in collected tear sample before, 5 and 10 minutes after provocation, were determined by radioimmunoassay. we obser-ved significant inhibitory effects on histamine release in eyes treated with HC, p<0.01 each at 5 and 10 minutes. The actual rate of inhibition of release of histamine amounted to 67.5% at 5 min-utes and 67.2% at 10 minutes. The findings seem to suggest the possible clinical usefulness of HC for Japanese cedar pollinosis.