雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Four cases of tubulointerstitial nephritis and uveitis syndrome Fumito Iida 1 , Yoshito Iida 2 , Hirotsugu Kitayama 3 1Iida Eye Clinic 2Department of Nephrology, International University of Health And Welfare Atami Hospital 3Department of Nephrology, Shizuoka Children's Hospital pp.1132-1138
Published Date 2024/9/15
DOI https://doi.org/10.11477/mf.1410215277
  • Abstract
  • Look Inside
  • Reference

Abstract Introduction:In this case series we outlined four cases of tubulointerstitial nephritis and uveitis(TINU)treated in our ophthalmology department and discussed the steps that led to the diagnosis.

Case 1:A 14-year-old girl with bilateral granulomatous iridocyclitis and goniotic nodules in the anterior segment was referred to the pediatric department of a general hospital due to high levels of cystatin C(CysC), creatinine, urinary N-acetylglucosaminidase(NAG), and urinary β2-microglobulin(β2-m). This patient was diagnosed with TINU based on clinical findings.

Case 2:A 10-year-old boy had right granulomatous iridocyclitis in the anterior segment of the eye and a goniotic nodule. There was no evidence of inflammation in the left eye. One month later, iridocyclitis developed in the left eye. Due to high levels of CRP, CysC, urinary NAG, and urinary β2-m, he was referred to the Department of Nephrology at Children's Hospital. TINU was confirmed by renal biopsy.

Case 3:A 15-year-old boy with bilateral granulomatous iridocyclitis in the anterior segment, angular nodules, optic disc swelling(+), high levels of CRP, CysC, and urine β2-m was referred to the nephrology department of Children's Hospital. TINU was confirmed by renal biopsy.

Case 4:An 8-year-old girl with right anterior segment granulomatous iridocyclitis and iris nodules was evaluated in our clinic. There were inflammatory cells in the anterior part of the vitreous and no evidence of inflammation in the left eye. Two months later, iridocyclitis developed in the left eye. Due to high levels of CRP, CysC, and urine β2-m, she was referred to the Department of Nephrology at Children's Hospital. TINU was confirmed by renal biopsy.

Results:Blood tests showed abnormal values for creatinine in one case and CysC in four cases, and urine tests showed abnormal values for NAG in two cases and β2-m in four cases, contributing to the diagnosis of tubulointerstitial nephritis.

Conclusion:In pediatric iridocyclitis, TINU is suspected regardless of whether it is in one or both eyes. In addition to regular kidney function tests, blood tests including CysC and urine tests including β2-m and NAG are required.


Copyright © 2024, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

関連文献

もっと見る

文献を共有