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A case of uveitis and orbital inflammation with hyperopic shift following systemic treatment with bisphosphonate Tomoko Fujimoto 1 , Tatsuro Miyamoto 1 , Mariko Egawa 1 , Yoshinori Mitamura 1 1Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School pp.989-995
Published Date 2018/7/15
DOI https://doi.org/10.11477/mf.1410212755
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Abstract Purpose:To report a case who developed uveitis and orbital inflammation with hyperopic shift following systemic treatment with bisphosphonate.

Case:A 77-year-old man was referred to us for pain and blurring of vision in the left eye. He had renal cell carcinoma with bone metastasis. The left eye developed hyperemia after the first and second session of intravenous infusion of zoledronate.

Findings and Clinical Course:Corrected visual acuity was 1.0 in either eye. The left eye showed hyperopia of +5 diopters. Intraocular pressure was 19 mmHg right and 25 mmHg left. The left eye showed restricted motility, proptosis, eyelid swelling, and signs of iritis. Optical coherence tomography showed thickening of the choroid in the left eye. Magnetic resonance imaging(MRI)showed thickened posterior wall of the eyeglobe. Discontinuation of zoledronate and topical corticosteroid was followed by improved ocular motility, reduced eyelid swelling, and decreased choroidal thickening. The left eye showed refraction of +2.5 diopters three weeks after his initial visit. There has been no recurrence for 17 months until present.

Conclusion:The present case illustrates that systemic treatment with bisphosphonate may induce uveitis and orbital inflammation with hyperopic shift.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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