防腐剤無添加ラタノプロスト点眼薬での点眼瓶の改良前後の使用感

Users' evaluation of preservative-free latanoprost ophthalmic solution in a modified container

要約　目的：ラタノプロストPF点眼薬は防腐剤を含有しないため角結膜に対する影響が少ないが，従来の点眼瓶は硬かった。点眼瓶の改良が行われたので，改良前後の点眼瓶の操作性や使用感を調査した。

対象と方法：ラタノプロストPF点眼薬を使用中の緑内障，高眼圧症患者72例を対象とし，点眼瓶改良前後の操作性や使用感について自己記述式アンケートを施行した。点眼瓶改良前後の眼圧を比較した。

結果：75％以上の症例で改良後に使用感が改善した。眼圧は，改良後1回目は有意に下降し，2回目は改良前と同等であった。

結論：ラタノプロストPF点眼薬の点眼瓶改良に伴い，使用感が改善した。適切な圧力で点眼液を適量押し出せる点眼瓶を用いることは有用である。

Abstract　Backgroud: Latanoprost PF is claimed to minimally affect the ocular surface as it does not contain benzalkonium chloride. Currently available latanoprost PF contains 2.5 ml of 0.005％ latanoprost per container that is not duly elastic.

Purpose: To evaluate latanoprost PF contained in a more elastic container.

Cases and Method: This prospective study was made on 72 outpatients who had been treated by latanoprost PF for 3 months or longer. The series comprised 13 males and 59 females. The age ranged from 29 to 87 years, average 67 years. There were normal-tension glaucoma 48 cases, primary open-angle glaucoma 14 cases and exfoliation glaucoma 5 cases among others. They were asked by questionnaire to report the subjective feeling after switching from the conventional to newly devised more elastic container for latanoprost PF.

Results: Sixty-two patients（86％）responded to the questionnaire. More than 75％ of patients felt more ease in the use of newly devised container. Intraocular pressure（IOP）decreased significantly at the first visit after change of container and was the same at the second.

Conclusion: Switching to newly devised more elastic container of latanoprost PF was evaluated as more easy to use by the patients.