浅前房，眼圧上昇，近視を伴った原田病の姉弟例

Harada's disease with shallow anterior chamber, myopia and intraocular pressure rise in a pair of siblings

　浅前房，眼圧上昇，近視化を伴った原田病の姉弟例を経験した．症例1は41歳の男性で浅前房，眼圧上昇を認めたため急性緑内障の診断で周辺虹彩切除を行った．その後近視および眼底に原田病特有の漿液性剥離を認めた．症例2は47歳女性で症例1の姉であり，経過中に浅前房，眼圧上昇，近視を認めた．

　眼圧上昇，浅前房，近視化の原因としては毛様体の浮腫が考えられた．HLA抗原の検索では，HLA-A24, HLA-CW1, DR-4が姉弟ともに陽性であった．

A 41-year-old male presented with clinical signs of acute closed angle glaucoma in both eyes. The left eye, which was in a severer state, underwent peripheral iridectomy as an emergency procedure. Later examinations revealed the presence of myo-pia, and serous retinal detachment and other char-acteristic features of Harada's disease in both eyes.

Nineteen months later, his sister, aged 47 years, developed acute clinical features of Harada's dis-ease including shallow anterior chamber, myopia and intraocular pressure rise. Swelling of the cilia-ry body seemed to be the cause for these clinical signs.

HLA studies showed positive A24, CW1 and DR4 in both cases in common.

Rinsho Ganka (Jpn J Clin Ophthalmol) 42(4) : 365-368, 1988