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原田病の発病後,比較的初期から観察できた3症例で,その経過中に炎症再燃に伴い瞳孔縁に虹彩結節(Koeppe結節)の出現を認めた.その後これらすべての症例はステロイドの減量に伴い炎症を反復し,炎症が遷延化したと考えられる経過を示した.また原田病70例の観察から,虹彩結節は遷延化した症例のみに見られる所見であることが明らかとなった.したがって細隙灯顕微鏡で簡単に観察できる虹彩結節は,原田病の炎症が遷延化したことを示唆する指標として有用であると考えられる.
We detected iris nodules along the pupillary margin (Koeppe nodules) in 3 cases of Harada's disease during periods of recurrence of uveal inflammation. The recur-rence of inflammatory attacks usually coincided with the decrease of systemic corticosteroids. Once the iris nodules appeared, the inflammation took a chronic and protracted course. Conversely, a retrospective survey of 70 cases of Harada's disease clarified that the iris nodules were found only in cases with chronic and delayed uveitis. Iris nodules would merit due attention as they are an important and easy-to-detect clinical sign of recurrence or procrastination of Harada's dis-ease.
Rinsho Ganka (Jpn J Clin Ophthalmol) 40(10): 1147-1150, 1986
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