Dipivalyl Epinephrine点眼液による角膜内皮細胞障害について

Effect of dipivalyl epinephrine on the corneal endothelium

　DPE点眼液によって家兎角膜内皮細胞に形態学的変化が生じることを光顕および電顕的に示した。この変化は一種の変性像であり，臨床的にDPE点眼液を使用するにあたっては角膜内皮細胞の障害に留意する必要があると推察された。

Dipivalyl epinephrine (0.1%) was administered in the cul-de-sac of rabbit eyes. Control study was performed with the eye drops in which DPE was removed. Six hours after the instillation of DPE, the endothelial cells were swollen and vacuoles were seen under light and electron microscope. After DPE eye drops were instilled twice a day for seven days, Descemet's membrane-like material was observed in the vacuoles and intercellular spaces.

The findings indicate that dipivalyl epinephrine can induce damages in the corneal endothelial cells when instilled topically.