Epinephrine点眼治療に不耐性であった緑内障患者へのDipivalyl Epinephrine点眼液の使用経験

Use of dipivalyl epinephrine in patients with intolerance to topical epinephrine

　Epinephrine （EP）点眼により副作用のみられた症例を主として，Dipivalyl epi—nephrine （DPE）点眼で副作用がどのように現われるかを検討し，あわせて眼圧下降作用をみた。EP点眼によるアレルギー性眼瞼皮膚炎34例において，DPE点眼では4例（12％）は同様の症状で中止したが，30例（88％）は無症状か軽症で継続使用可能であった。結膜充血，アレルギー性結膜炎，鼻粘膜刺激症状，頭痛でも，DPEでは副作用例ははるかに少数であった。眼圧下降作用については0.1％DPE点眼は1.25％EPと同程度かそれ以上の効果があると思われる。

Topical instillation of 0.1% dipivalyl epinephrine (DPE) was applied to 34 glaucoma cases who de-veloped allergic blepharitis by epinephrine eye-drops. DPE instillation was well tolerated with-out any allergic signs in 19 cases (58%). Slight dermatitis developed initially in 11 cases (30%). It disappeared in 5 of them during subsequent con-tinuous use. Use of DPE had to be discontinued in 4 cases (12%) due to dermatitis which was es-sentially similar to that caused by epinephrine. DPE instillation has thus been continued in 30 cases except the 4 cases above.