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緑膿菌性眼感染症5例に対して,新しいセファロスポリン,Cefoperazone (T−1551)を全身,局所投与して臨床効果を検討した。
緑膿菌性角膜潰瘍の4例には,すぐれた臨床効果がみとめられた。全眼球炎の1例は眼球内容除去術を行ったが,硝子体内細菌数の減少がみられた。
副作用として,3例に発疹がみられた。その他,検血,肝腎機能検査値に異常をみとめなかった。
Four cases of pseudomonas corneal ulcer were treated with new cephalosporin, Cefoperazone (CPZ) by means of instillation, 50mg~ 100mg subconjunctival injection and drip infusion or intramuscular injection 1~2g once or twice The cli- nical results were excellent in one case and good in 3 cases.
Although a case of pseudomonas panophthalmitis progressed without clinical improvement in spite of treatment with CPZ and evisceration was perform-ed,bacterial count of Ps. acruginosa in the vitreous was decreased.
In 3 eases, rash developed but disappeared promptly after cessation of drug.
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