眼精疲労に対するビタミンB12点眼液の薬効について—二重盲検法による薬効判定

A duoble blind study on the effectiveness of vitamin B12 ophthalmic solution on asthenopia

緒　言

　眼精疲労をきたす原因としては，単に視器的要因のみではなく，全身疾患，精神的状態および環境状態など種々の因子が考えられ，しばしば，これらの因子が複合して存在している。

　したがつて，眼精疲労を訴える患者から，明らかな単一の発生要因を探り出せないことが多く，近代病の一つとして最近増加の傾向を示している本症の対策に悩まされる場合も稀ではない。

Improvement effect of vitamin B₁₂ ophthalmic solution (0.02% cyanocobalamine ophthalmic so-lution) on the accommodative function was stu-died with double blind test by using as index the results obtained from four kinds of accom-modative function tests : the repeated measure-ment of the accommodation (contraction and relaxation) time by accommodopolyrecorder, the measurement of the accommodation movement (photoelectric accoinmodogram : PEAG) and the floating accommodation (so-called "small fluctua-tion of accommodation" according to Campbell) by infrared recording optometer and the repe-ated measurement of the near-point ofac commo-dation by Ishihara's Near-Point Meter. Fourty-five patients (90 eyes) with accommodative ast-henopia served as subjects for the study and vi-tamin B12 ophthalmic solution was instilled 4 times a clay for 2 weeks. The obtained results were as follows :

1. There were no significant differences in background examination on patients' sex, age,the existence of refractive errors and initial va-lues of accommodative function tests between the two groups of vitamin B12 ophthalmic solu-tion (Group A) and placebo ophthalmic solution (Group P) each being administered at random. They were appropriate for comparative study.