顆粒状角膜変性症の一家系

Clinical Manifestation of Corneal Granular Dystrophy in a Pedigree

緒言

　顆粒状角膜変性症はGroenowによつて初めて報告されて以来，内外を通じ多くの報告があり，決して珍しい疾患ではない。しかしその進行過程を観察した研究はきわめてまれである。今回私は一家系内に初発症状，進行過程および吸収過程を示すと思われるいろいろの型の角膜混濁を示す患者を観察する機会を得たので報告する。

Granular dystrophy of the cornea (Groenow) was detected in 6 members of a pedigree ran-ging over 3 generations. A wide variety in the severity of corneal affection could be observed among the affected members.

In the early phase, the corneal affection ap-peared as small dots and radial lines located in the epithelium and the Bowman's membrane. This type was found in 3 younger subjects of 11, 17 and 19 years of age.

A more advanced phase was seen in a 48-year-old subject. Opacities in the shape of dots, discs or chains were located in the Bow-man's membrane and the anterior stromal layer of the cornea.