向精神薬服用患者でみられた水晶体の変化について

Lens Changes Induced by Long-Term Psychotropic Agents

緒言

　向精神薬を服用している患者の水晶体変化の性状，投与量，服用期間等の関係についてはすでにいくつかの報告がみられ^1〜8），われわれも前報^9）にて検討したが，今回はその後に当科外来で観察した2例を加えた9症例について検討し，そのうちで完全混濁例に嚢内摘出術を施行し，特に上皮細胞の電顕的観察を行なつたので報告する。

Lens changes associated with long-term treat-ment with psychotropics, mainly chlorpromazi-ne, were studied in 9 mentally ill patients. Their ages averaged 33 years.

Various characteristic lens opacities were detected by slitlamp examination. Four patients showed fine powdery or partially punctate spots on the extreme surface of the lens at theanterior polar region. The other 5 patients showed either punctate, radial, starfish-shaped or complete lens opacities.

Intracapsular lens extraction was performed for both eyes of a patient showing complete lens opacity and the removed lens was submi-tted to electron microscopic studies.