精神病患者に多発せる眼科的異常所見について

Drug-induced Cataract in Mentally-ill Subjects

緒言

　著者^1）は，向精神薬を投与された精神病院入院患者のなかに眼科的に異常所見を呈するものがいることを報告した。今回はその患者の視力の推移と組織学的所見並びに手術によりえられた若干の知見について報告する。

An unsual form of capsular cataract has been observed in an increasing frequncy in schizo-phrenic patient under long-term treatment with butyrophenol derivatives. Once after the cata-ract has started, it has a tendency to aggra-vate rapidly so that the vision is severely affected within a short period.

Eight eyes in seven patients with this type of cataract have been operated. Histological studies have shown that the lens opacity is chiefly due to degenerative process in the cor-tical region. Large, round "balloon cells" were located in the subepithelial layer in the equator.