緑内障眼における2機種のスペクトラルドメインOCTによる網膜神経節細胞複合体厚および網膜神経線維層厚と視野障害の関係

Correlation between visual field loss and thickness of retinal nerve fiber layerin the circumpapillary and macular ganglion cell complex by two types of spectral-domain optical coherence tomograph in glaucomatous eyes

要約　目的：スペクトラルドメイン光干渉断層計（SD-OCT）で測定された緑内障眼の黄斑部網膜神経節細胞複合体（GCC）厚および乳頭周囲網膜神経線維層（cpRNFL）厚と視野障害の関係の報告。対象と方法：広義原発開放隅角緑内障23例41眼を対象とした。2機種（RTVue-100，RS-3000）のSD-OCTでGCC厚，cpRNFL厚を測定した。視野検査はHumphrey視野計で測定し，中心30-2のMD値とVFI，トータル偏差で評価した。GCC厚，cpRNFL厚はBland-Altman plot解析を用い分析し，視野指標との関係は回帰分析を用い評価した。結果：直径9mmのGCC厚は視野指標と強く相関していた。RTVue-100とRS-3000のGCC厚に有意な差があった。RS-3000のGCC厚およびcpRNFL厚は，RTVue-100に対して比例誤差が生じた。結論：2機種のGCC厚およびcpRNFL厚は視野障害と有意に相関していた。RTVue-100とRS-3000のGCC厚は有意に相関していたが，機種間で値は異なることが示された。

Abstract.　Purpose：To report the correlation between visual field loss and thickness of retinal nerve fiber layer in the circumpapillary（cpRNFL）and macular ganglion cell complex（GCC）using two spectral-domain optical coherence tomograph（SD-OCT）instruments. Cases and Methods：Forty-one eyes of 23 patients with primary open-angle glaucoma were evaluated by RTVue-100 and RS-3000. Visual field was evaluated by MD value, VFI and total deviation measured Humphrey perimetry. The relationship between retinal structure and visual field indices was evaluated by Bland-Altman analysis and regression analysis. Results：GCC thickness of 9 mm in diameter significantly correlated with visual field index. Although GCC and cpRNFL measurements were highly correlated between the instruments, the Bland-Altman analysis revealed proportional biases. Conclusion：GCC and cpRNFL thickness of the two SD-OCT instruments were significantly correlated with visual field parameters. GCC measurements were well correlated between the instruments but had different values for thickness.