乳癌の眼窩転移に対して定位放射線治療を行った1例

A case of orbital metastasis from breast cancer treated by stereotactic radiotherapy

要約　目的：乳癌の眼窩転移に対して定位照射線治療を行った症例の報告。症例：41歳女性が右上眼瞼の違和感で受診した。10か月前に全身転移がある左進行性乳癌と診断され，抗癌剤による治療を受けていた。所見：右眼に眼瞼下垂があり，上眼瞼皮下に腫瘤を触知した。MRIで眼窩上縁に腫瘤があり，FDP-PETで同部位にFDPの強い集積があった。眼窩腫瘍の生検で，乳癌の眼窩転移を診断した。眼窩転移に対し65Gyを26回に分割する定位放射線照射を行った。6か月後に腫瘍は消失し，以後9か月後の現在まで再発はない。結論：乳癌の眼窩転移に対する定位放射線治療は，副作用が少なく有効であった。

Abstract.　Purpose：To report a case of orbital metastasis from breast cancer treated by stereotactic radiotherapy. Case：A 41-year-old woman presented with discomfort in her right eye. She had been diagnosed with advanced breast carcinoma with systemic metastases 10 months before and been receiving systemic chemotherapy. Findings：The right eye showed blepharoptosis. A tumor was present posterior to the upper eyelid. Magnetic resonance imaging（MRI）showed a tumor near the upper orbital margin. F-18 fluorodexy glucose positron emission tomography（FDP-PET）showed massive accumulation of FDP. Biopsy led to the diagnosis of metastasis from breast cancer. The orbital tumor was treated by stereotactic radiotherapy totalling 65Gy applied in 26 sessions. The tumor regressed 6 months later. There has been no recurrence for 9 months until present. Conclusion：Stereotactic radiotherapy was safe and effective for orbital metastasis from breast cancer.