眼付属器MALTリンパ腫10例の検討

Review of ten cases of mucosa-associated lymphoid tissue（MALT）lymphoma in the ocular adnexa

要約　目的：眼付属器粘膜関連リンパ組織（MALT）リンパ腫10例の治療成績の報告。対象と方法：過去5年間のMALTリンパ腫10例を診療録の記述に基づいて検索した。結果：男性5例，女性5例で，全例が眼部に限局していた。4例が片眼，6例が両眼発症で，年齢は35～72歳（平均58歳）である。腫瘍は6例では結膜に限局し，4例は眼窩結合織原発であった。8例は放射線治療，3例がリツキシマブによる化学療法を受けた。放射線総量は病変部局所で32～38Gyであった。6～48か月（平均26か月）の経過観察で，治療を受けた全例で病変が縮小し，再発はなかった。結論：眼付属器MALTリンパ腫に対し，放射線照射は有効である。

Abstract.　Purpose：To report the outcome of treatment in ten cases of mucosa-associated lymphoid tissue（MALT）lymphoma of ocular adnexa. Cases and Method：This retrospective study was made on 10 cases of MALT lymphoma of ocular adnexa seen during the past 5 years. Results：The series comprised 5 males and 5 females. The age ranged from 35 to 72 years,average 58 years. The tumor was localized in the eye or the orbit in all the cases. It was bilateral in 6 cases and unilateral in 4. The tumor was present in the conjunctiva in 6 cases and in the orbital connective tissue in 4. Eight cases were treated by radiation and 3 cases received systemic rituximab. The dosis of radiation totaled 32 to 38 Gy in the eye region. After follow-up for 6 to 48 months,average 26 months,the tumor regressed in all the treated cases with no recurrence. Conclusion：Radiotherapy is effective for MALT lymphoma of the ocular adnexa.