久留米大学眼科における12年間のBehçet病の検討

A twelve-year review of Behçet disease in Kurume University Hospital

要約　目的：久留米大学眼科でのBehçet病の臨床経過と視力転帰の報告。対象と方法：2006年までの12年間に久留米大学眼科でBehçet病と診断した31例を検索した。全例で7か月～12年（平均6.4±3.8年）の経過を観察した。男性25例，女性6例で，男女比は1：0.24であった。結果：眼症状は21～58歳（平均37.5歳）で出現した。27例が両眼に発症し，4例が片眼性で，完全型9例，不全型22例であった。眼炎症発作は年間0.3～9.5回起こり，免疫抑制薬の投与前は平均5.2回，投与後は2.9回であった。治療としては全例にコルヒチンを投与し，さらに18例（55％）には免疫抑制薬を使用した。神経Behçet病5例のうち4例が最終視力0.1未満であった。視力不良な症例は，免疫抑制薬を使用しているものが有意に多かった。結論：Behçet病の眼炎症発作に対し，免疫抑制薬は有効であるが，最終視力が不良である症例が多い。

Abstract.　Purpose：To present a 12-year review of Behçet disease. Cases and Method：This study was made on 31 cases who were diagnosed with Behçet disease during 12 years through 2006. Cases were followed up from 7 months to 12 years,average 6.4±3.8 years. The series comprised 25 males and 6 females,resulting in male-to-female ratio of 1：0.24. Results：Ocular symptoms first appeared at the age of 21 to 58 years,average 37.5 years. Both eyes were involved in 27 cases and one eye only was involved in 4 cases. Behçet disease was complete in 9 cases and incomplete in 22 cases. Ocular attack occurred from 0.3 to 9.5 times per year. It occurred 5.2 times per year before introduction of immunosuppressants and 2.9 times after introduction. All the cases received systemic colchicines. In addition,18 cases（55％）received immunosuppressive drug. Final visual acuity was less than 0.1 in 4 out of 5 cases of neuro-Behçet disease. Final visual acuity was significantly poor in cases receiving immunosuppressants. Conclusion：Immunosuppressive drugs were effective for acute ocular attacks in Behçet disease but resulted in poor final visual acuity.