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A fifteen-year review of Vogt-Koyanagi-Harada disease Rumiko Inoue 1 , Chikako Taguchi 1 , Sumie Kawahara 1 , Ryoji Yamakawa 1 1Dept of Ophthalmol,Kurume Univ Sch of Med pp.1431-1434
Published Date 2011/9/15
DOI https://doi.org/10.11477/mf.1410103828
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Abstract. Purpose:To present a review of Vogt-Koyanagi-Harada(VKF)disease in the past 15 years. Cases and Method:This retrospective study was made on 117 cases of VKH disease who were first seen by us during 15 years through 2009. The series comprised 42 males and 75 females. The age ranged from 15 to 76 years,average 45 years. Results:Fifty-five cases were initially treated by high-dose corticosteroid followed by tapering,53 cases by pulsed corticosteroid,7 cases by topical corticosteroid,and 2 cases by peroral corticosteroid. The disease recurred or relapsed in 33 cases,22 of which resulted in protracted course. Eighteen eyes resulted in final visual acuity of 0.5 or less. These eyes were mainly those with recurrence or relapse of the disease. Cases treated by high-dose corticosteroid followed by tapering often resulted in multiple recurrence and sunset-glow fundus. Conclusion:Recurrence and protracted course are major factors for poor visual outcome. Multiple recurrences and sunset-glow fundus were more frequent in cases treated by high-dose corticosteroid followed by tapering than pulsed corticosteroid.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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