加齢黄斑変性症に対するベバシズマブ併用光線力学療法

Treatment of age-related macular degeneration by intravitreal bevacizumab followed by photodynamic therapy

要約　目的：加齢黄斑変性に対し，硝子体内ベバシズマブ注入に光線力学療法を併用した成績の報告。対象と方法：出血性または漿液性網膜色素上皮剝離を伴う加齢黄斑変性6眼6例を対象とした。男性4例，女性2例で，年齢は60～88歳（平均73歳）である。ベバシズマブ1.25mgを硝子体内に注入し，その翌日に光線力学療法を実施した。視力はlogMARで評価した。結果：6か月後の視力は，2眼（33％）で不変，4眼（67％）で2段階以上改善した。網膜色素上皮剝離は5眼で消退した。結論：網膜色素上皮剝離を伴う加齢黄斑変性に対し，硝子体内ベバシズマブ注入と光線力学療法の併用は有効なことがある。

Abstract.　Purpose：To report the outcome of age-related macular degeneration treated by intravitreal bevacizumab followed by photodynamic therapy. Cases and Method：This retrospective study was made on 6 eyes of 6 patients of age-related macular degeneration associated with serous or hemorrhagic detachment of retinal pigment epithelium. The series comprised 4 males and 2 females. The age ranged from 60 to 88 years, average 73 years. Each case received intravitreal injection of 1.25mg bevacizumab followed by photodynamic therapy the next day. Visual acuity was evaluated in terms of logMAR. Results：Six month after treatment, visual acuity improved by 2 lines or more in 4 eyes（67％）and remained unchanged in 2 eyes（33％）. Detachment of retinal pigment epithelium regressed in 5 eyes. Conclusion：Intravitreal bevacizumab followed by photodynamic therapy may be effective for age-related macular degeneration associated with detachment of retinal pigment epithelium.