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Japanese

Conservative treatment of retinoblastoma with selective injection of melphalan into the ophthalmic artery Seiji Takagi 1 , Akihiro Kaneko 1 , Taku Kaneko 1 , Shinobu Takeuchi 1 , Kei Takahashi 2 , Toshiaki Oharazeki 2 , Makoto Mohri 3 1Dept of Ophthalmol, Toho Univ Med Cent, Ohashi Hosp 2Dept of Pathol, Toho Univ Med Cent, Ohashi Hosp 3Dept of Radiol, Toho Univ Med Cent, Ohashi Hosp pp.1923-1930
Published Date 2007/10/15
DOI https://doi.org/10.11477/mf.1410101969
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Abstract. Purpose:To report treatment of retinoblastoma with selective injection of melphalan into the ophthalmic artery. Cases:This study was made on 10 eyes of 7 cases of retinoblastoma who received conservative treatment during the past 18 months. The series comprised 2 males and 5 females. Retinoblastoma was unilateral in 4 cases and bilateral in 3. The age ranged from one to 20 months, median 16 months. Stage of retinoblastoma was Ⅰb 3 eyes, Ⅱa 4 eyes, Ⅲb one eye, and Ⅴb 2 eyes. Method:All the cases received, initially, 2 courses of VEC(vincristine, etoposide and carboplatine). Following treatments were performed depending on the fundus findings:injection of melphalan into the ophthalmic artery and vitreous, transpupillary thermotherapy, brachytherapy with ruthenium, or enuculeation. Results:Injection of melphalan was performed in 10 eyes in 31 sessions during a 10-month period. Cure was obtained in 5 eyes, was expected in one eye, 2 eyes were still under treatment, and enucleation was performed on 2 eyes. Complication was absent throughout. Conclusion:Selective injection of melphalan into the ophthalmic artery is safe and effective for retinoblastoma with minimum systemic side effects and short hospitalization.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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