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Clinical features and ultrastructure of keratoconus in a case of Down syndrome Chioko Maruta 1 , Michiko Oba 1 , Azusa Fujikawa 1 , Ryo Taniguchi 1 , Yumiko Takami 1 , Takashi Kitaoka 1 , Tsugio Amemiya 1 1Dept of Opthalmmol and Visual Sci,Grad Sch of Biomed Sci,Nagasaki Univ pp.941-944
Published Date 2004/6/15
DOI https://doi.org/10.11477/mf.1410100599
  • Abstract
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 A 26-year-old female with Down syndrome presented with hyperemia and opaque cornea in her right eye since 12 days before. Her visual acuity was 0.3 right and 0.5 left when corrected by-16 diopters each. Both eyes had keratoconus. The right eye had acute hydrops due to ruptured Descemet membrane. The right eye received penetrating keratoplasty for bullous keratopathy 28months later. The cornea showed following features by electron micro-scopy. Epithelial basement membrane was disoriented and interrupted. Bowman layer was thin containing high-density substances. Stromal cells showed polymorphism with disoriented collagen fibrils. Descemet membrane was tortuous. Endothelial cells were destroyed. These findings corresponded well to clinically observed stromal and epithelial edema.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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