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Hyperviscosity syndrome in a case of polyclonal hypergammaglobulinemia Haruka Ohshima 1 , Shinji Makino 1 , Chika Kondo 1 , Sadao Kanagami 1 , Tadahiko Tsuru 1 1Dept of Ophthalmol,Jichi Med Sch pp.309-313
Published Date 2004/3/15
DOI https://doi.org/10.11477/mf.1410100531
  • Abstract
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 A 72-year-old woman was referred to us for retinal hemorrhage. She had noticed blurring of vision 4months before. Her corrected visual acuity was 0.5 right and 0.3 left. The retinal vessels showed marked beading and tortuosity. There were,additionally,retinal and vitreous hemorrhage,capillary microaneurysms,and macular edema. The peripheral retina had become avascular. These findings were suggestive of hyperviscosity syndrome. Laboratory studies showed anemia and rouleau formation of erythrocytes. Serum proteins showed increased levels of 10.8g/dl for total protein,4,205mg/dl for IgG,463mg/dl for IgM,and 719mg/dl for IgA. Immunoelectrophoresis showed polyclonal hypergammaglobulinemia. The serum viscosity was 12.2cP. We diagnosed her as retinopathy seconary to hyperviscosity syndrome. She was treated by systemic anticoagulants and photocoagulation to the peripheral retina. After 8months,the serum viscosity decreased to 9.16cP. Funduscopy showed improved venous beading,tortuosity,and macular edema. The visual acuity improved to 0.6 right and 0.5 left. This case illustrates that hyperviscosity retinopathy may be reversible following successful anticoagulant therapy.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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