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Efficacy of Intravenous Bisphosphonate Therapy for Spinal Deformities Associated with Osteogenesis Imperfecta Sadaaki KANAYAMA 1 , Masafumi KASHII 1 , Taichi KITAOKA 2 , Takahiro MAKINO 1 , Takashi KAITO 1 , Tsuneo SHIGI 3 , Takuo KUBOTA 2 , Noriyuki NAMBA 2 , Takehisa YAMAMOTO 4 , Keiichi OZONO 2 , Motoki IWASAKI 1 , Hideki YOSHIKAWA 1 1Department of Orthopedic Surgery, Graduate School of Medicine Osaka University 2Department of Pediatrics, Graduate School of Medicine Osaka University 3Department of Orthopedic Surgery, Minoh City Hospital 4Department of Pediatrics, Minoh City Hospital Keyword: 骨形成不全症 , osteogenesis imperfecta , 脊柱変形 , spinal deformity , ビスフォスフォネート , bisphosphonate pp.917-924
Published Date 2014/10/25
DOI https://doi.org/10.11477/mf.1408200019
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 Background:Bisphosphonate (BP) is used to prevent fragility fractures and subsequent bony deformities associated with osteogenesis imperfecta (OI), but few studies have investigated the incidence and progression of spinal deformities in OI patients treated with BP.

 Methods:The cases of 40 OI patients treated by cyclic intravenous BP administration were reviewed to determine the prevalence of scoliotic deformity and to identify risk factors for the development of scoliotic deformity.

 Results:The prevalence of scoliotic deformity in this study was 22.5%, and the incidences of scoliotic deformity and coronal vertebral deformity were lower than in previous reports. A high body mass index and Sillence type III and type IV are risk factors for the development of scoliotic deformity. BP therapy starting in early childhood prevented the development of scoliosis in Sillence type III and type IV OI patients.

 Conclusion:The results of this study showed that BP therapy effectively prevented the development of coronal vertebral deformity associated with bone fragility in OI patients and decreased the subsequent development and progression of scoliosis.


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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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