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Japanese

Remyelination by Schwann Cell Trnsplantation for CNS Demyelinated Axons:Functional Comparison with Developmental Myelination Toshio Imaizumi 1 , Syuuichi Tsushima 1 , Masanori Sasaki 1 , Yukinori Akiyama 1 , Kazuo Hashi 1 1Department of Neurosurgery, Sapporo Medical University School of Medicine Keyword: CNS , development , remyelination , transplantation , Schwann cell pp.701-707
Published Date 2000/8/1
DOI https://doi.org/10.11477/mf.1406901637
  • Abstract
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Transplantation of Schwann cells (SCs) induced re-myelination of demyelinated rat dorsal column (DC) axons and improved conduction. To investigate the dif-ference between developmental oligodendrocytic mye-lination and SC myelination in conductive functions of axons, we compared normaly developmantal DCs (10 days old, 22-23 days old, and adult rat), demyelinated DCs, and remyelinated DCs by SC transplantation.

DCs of adult rats were demyelinated at T 11 by X-ray irradiation and ethidium bromide, and trans-planted with SCs (3×104) of adult rats.


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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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