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The Role of Transplanted Astrocytes for The Regeneration of CNS Axons Toshio Imaizumi 1,3 , Karen L Lankford 3 , Jeffery D Kocsis 3 , Kazuo Hashi 2 1Department of Neurosurgery, Hakodate Municipal Hospital 2Department of Neurosurgery, Sapporo Medical University School of Medicine 3Department of Neurology, Yale University School of Medicine, Neuroscience Research Center Keyword: CNS axon , regeneration , transplantation , Schwann cell , astrocyte pp.632-638
Published Date 2001/7/1
DOI https://doi.org/10.11477/mf.1406901797
  • Abstract
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Long tract axons in the mammalian CNS do not normally regenerate for appreciable distance after they transected. But we reported transplantation of Schwann cells (SCs) or olfactory ensheathing cells in-duced regeneration of transected rat dorsal column (DC) axons and improved the conduction.

Scar formation (gliosis), for which astrocytes (ACs) play an important role, may be one of strong and physical barriers for the regeneration of CNS axon. Oligodendrocyte and myelin associated protein or products also inhibit the regeneration of the axons, as chemical harriers.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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