Changes in Cerebral Extracellular pH, Cerebral Blood Flow and Intracranial Pressure Induced by Hypercarbic Ventilation: Assessment as a Potential in Vivo Model of Cerebral Acidosis Masaki Niiro 1 , Koki Kadota 1 , Tetsuhiko Asakura 1 , Roger P Simon 2 1Department of Neurosurgery, University of Kagoshima Keyword: extracellular brain pH , acidosis , Co2 , CBF , ICP pp.639-645
Published Date 1994/7/1
DOI https://doi.org/10.11477/mf.1406900657
  • Abstract
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The effects of acidosis on ischemic brain damage are unclear and probably diverse. To establish an in vivo model of acidosis, the authors assess changes in extracellular brain pH (pHe) , CBF and ICP induced by hypercarbic ventilation, and discuss the reliabi-lity and short comings of this experimental model. Acidosis was induced by increasing the inspired CO2 concentration in mechanically ventilated rats. pHe was measured with a pH-sensitive electrode im-planted into the cortical mantle.

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