悪性脳腫瘍に対する放射線化学療法の非病巣部脳血流量への影響—Single photon emission CTによる検討

Cerebral Blood Flow of the Non-affected Brain in Patients with Malignat Brain Tumors as Studied by SPECT; With special reference to adverse effects of radiochemotherapy

I．はじめに

　脳腫瘍に対する放射線化学療法は腫瘍自身の循環代謝の低下^18）を招来させると同時に，一方では，非病巣部の脳壊死などの器質的変化の出現に先行して，循環代謝の変化が認められることが報告されている^3,7,12）．

　正常脳では脳血流量と脳代謝量は一致した動きを示すが，病的状態においては，異なった変化を示す^9）ため，正確な循環動態の把握には両者の測定が必要である．しかし，脳血流量は比較的測定が容易なため，脳機能を客観的に評価するには有効な手段となる．

The mean cerebral blood flow (mCBF) has been stu-died in 40 patients with brain tumors undergoing radia-tion and chemotherapy, and with ages ranging from 20 to 69 years, using ¹³³Xe and single photon emission CT. A comparison was made of mCBF of 40 normal volun-teers (34 males and 6 females) whose ages ranged from 25 to 82 years.

The results were as follows: Some patients exhibited increased mCBF during external irradiation therapy.