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AN EFFECT OF VINCAMINE AND ITS ANALOGUES ON CEREBRAL CIRCULATION IN DOGS Tetsuji Imamoto 1 , Tadaatsu Nukada 1 , Kunihiko Tada 1 1First Department of Internal Medicine, Osaka University Medical School pp.341-347
Published Date 1977/3/1
DOI https://doi.org/10.11477/mf.1406204043
  • Abstract
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Vincamine is an alkaloid of Vinca minor Linne.This study was performed to evaluate the effects ofvincamine on cerebral and peripheral circulationsin dogs.

Mongrel dogs were anesthetized by pentobarbitalsodium and managed under an intubated respiration.The arterial blood pressure was monitored througha canulated femoral artery. The femoral blood flowwas measured in the other side by means of electromagnetic flowmeter. Heart rate was calculated fromR-R interval on the ECG recording pattern. Theinfluence of vincamine on cerebral circulation wasevaluated by the measurement of subcortical bloodflow change and sagittal sinus flow. Subcorticallocal cerebral blood flow change was detected bya heat clearance method. The sagittal sinus flowvelocity was measured by ultrasonic doppler tech-nique and sinus pressure was measured throughthe catheter inserted into the sinus. These he-modynamic parameters were recorded simultaneou-sly by means of the polygraphy.

The effects of the intravenous bolus injectionof vincamine at dosis of 0.5, 1.0, 1.5, 2.0, 3.0 and4.0mg per kg of body weight on cerebral andsystemic circulations were observed in comparisonwith papaverine effect. The intravenous bolusinjection of vincamine at dosis of above 1.0mgper kg of body weight produced a marked increasein subcortical cerebral blood flow, sinus pressureand sinus flow velocity. This effect was shorterin a duration of action, less in lowering arterialblood pressure and less in increasing heart ratethan each that of papaverine hydrochloride. Withregard to dose response, the optimal dose of vinca-mine to increase cerebral blood flow was 1.5mgper kg in dogs. The intravenous drip infusion ofvincamine at dose of 0.60 mg per kg of body weightper minute for ten minutes maintained approxima-tely eight percent increase in local subcortical ce-rebral blood flow.

Both 3-epivincamine and apovincamine whichwere vincamine analogues were as effective as vin-camine with regard to increase in cerebral bloodflow.

It was suggested that vincamine, 3-epivincamineand apovincamine had marked increasing effectson cerebral and peripheral blood flow but effectedlittle on cardiovascular system.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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