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Brain and Nerve No to Shinkei Volume 26, Issue 10 （October 1974）

Brain and Nerve 脳と神経 26巻10号（1974年10月発行）

Japanese English

原著

HEAT CLEARANCE法による局所脳血流測定とFLUNARIZINEの脳血流におよぼす影響 AN IMPROVED MEASUREMENT OF REGIONAL CEREBRAL BLOOD FLOW WITH HEAT CLEARANCE METHOD AND AN EFFECT OF FLUNARIZINE ON CEREBRAL CIRCULATION 多田邦彦 ¹ , 青山喬 ¹ , 米田正太郎 ¹ , 栗山良紘 ¹ , 額田忠篤 ¹ Kunihiko Tada ¹ , Takashi Aoyama ¹ , Shotaro Yoneda ¹ , Yoshihiro Kuriyama ¹ , Tadaatsu Nukada ¹ ¹大阪大学医学部阿部内科脈管研究室 ¹First Department of Internal Medicine, Osaka University Medical School pp.1023-1029

発行日 1974年10月1日 Published Date 1974/10/1

DOI https://doi.org/10.11477/mf.1406203612

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Abstract 文献概要
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I．序

　脳循環動態の測定は，古くForbes^1），Fog^2）の頭窓法による脳軟膜血管の観察にはじまるが，その後の測定方法の進歩はまことに目ざましく，最近では，Xe-133，Kr-85，Tc-99mなどの放射性物質を使用した脳循環諸量の測定が行なわれるようになつた。

　Gibbs^3）によつて創始されたheat clearance法による局所組織血流測定法は，ある時間的一断面における血流最を定量的に測定する放射牲物質を使用する方法と異り，経時的に組織の循環動態をとらえ得る優れた動態計測の一手段であり，脳血流量測定にも応用されている。また脳循環改善剤の評価の面からも，この経時的な脳血流測定法は有用である。

A divice was made to record the change of cere-bral blood flow in subcortical structure. A double needle type thermocouple probe was used to measure the difference in temparature between the heated and unheated junction. The principle of heat clearance method was based on the facts that the temparature of a constantly heated point in a per-fused homogenous tissue was dependent on the conduction of heat through the tissue, on the con-vection of heat by the blood flow and on the heat production of the tissue.

A model experiment using liquid paraffin in a rubber tube was performed to determine the relation between the out flow rate of paraffin and the thermoelectromotive force increment. A good cor-relation was found and this correlation was not influenced by the alteration of the liquid tempara-ture at 37℃ and 42℃. Possible problems in using heat clearance method such as the heat conduction from the heated junction to the unheated junction through the tissue, the relation between the heated junction and the direction of blood stream at the placement of a probe into the tissue, the determina-tion of the zero point of blood flow and the in-fluence of metabolic heat production were able to be solved in measuring of regional cerebral blood flow.

An effect of Flunarizine which was a Cinnarizine derivative and a potent vasodilator of peripheral vessels on cerebral circulation was studied. The intravenous administration of Flunarizine in a dose of 1 mg per kg of body weight proved a marked increase in subcortical cerebral blood flow of the dogs. This effect was in excess of two times longer lasting than that of Papaverine hydrochloride. On the dose response study, the optimum dosage of Flunarizine to cerebral blood flow was 0.75 mg per kg in the dogs.