Japanese

THREE PATTERNS ON THE GLASS SURFACE PRODUCED BY CULTURED ASTROCYTOMA-GLIOBLASTOMA-SERIES Shizuo MIYAKE 1 , Mitsuo TOYAMA 2 , Seishi FUKUMA 2 , Yoshihiro FUJITA 1 , Bunzo NISHIOKA 1 , Tsuguo TANAKA 1 , Akihisa KOIKE 1 1Department of Pathology, Kyoto Prefectural University of Medicine 2Department of Surgery. Kyoto Prefectural University of Medicine pp.593-600
Published Date 1968/6/1
DOI https://doi.org/10.11477/mf.1406202388
  • Abstract
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The cellular patterns on the glass surface produced by cultured human brain tumor cells (40 cases of astrocytoma-glioblastoma-series) after trypsinization, can be classified into three types, resulting to cor-respond the histological malingnancy of neoplasms, namely I-type by benign astrocytoma, II-type by atypical astrocytoma including spongioblastoma and ependymoma, and III-type by glioblastoma multi-forme. These patterns in vitro have characteris-tic contours and relationship of cells, owing to the morphological type in vivo respectively, although transitional gradings are seen in them. Fundamen-tally, however, neoplastic cells participating to those typing have to originate from the glial elements, whatever, bizarre features they present on the glass surface. The authors confirmed that the fibrilar astrocytoma of 2-year-old-female infant revealed the I-type pattern at the first operation, and the recurring tumor obtanined at the second operation two years after, exhibited the pleomorphic pattern with bizarre giant cells in vitro, possibly classified as II and/or III-type, beeing substanciated that the two kinds of cells belonged to the same glial system. Our further contribution on tissue culture of glial tumors covers very few aspect of ,tumor classifica-tion, but much of prospect of biological behaviors in the tumor in vivo that would determine their fate.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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