実験的急性眠剤中毒の脳波に対するCDP-cholineの影響

EFFECT OF CDP-CHOLINE ON EEG OF ACUTE HYPNOTIC POISONING

I．はじめに

　意識障害にはさまざまの原因があるが，障害の度と持続の時間とは生命の予後に直接のつながりをもつことが多く，したがつて速やかにその原因を鑑別するとともに，積極的に意識の回復をはかる処置がなされねばならない。

　脳神経外科領域において最近，脳損傷時の意識障書に対するCDP-cholineの効果が報告され，その後動物並びに臨床の成績からこのものが意識障害の改善にすぐれた効果をもつことが証明されている。そこで意識障害を主症状とする急性眠剤中毒に対してもなんらかの影響を及ぼすであろうことが推測できる。

In 8 rabbits with experimentally induced hypnotic poisoning, 100 mg of CDP-choline were injected intravenously at one time or more and their EEG changes were observed. In all cases their EEG showed a tendency of recovery after CDP-choline injection, in 5 cases their EEG showed arousal pat-terns in 30 to 40 minutes after injection. Their effective periods of CDP-choline were about 40 to 60 minutes, after this period EEG changes returned imediately to patterns of the untreated period. These effects of repeated administration appeared more rapidly and continued than on first administ-ration. Their effects were transient and we suspect that the repeated or continuous administration of CDP-choline will be good results. CDP-choline is supposed to be an effective drug on the treatment of unconsciousness of acute hypnotic poisoning as well as head injuries.